Research Fellowship

Transforming growth factor-β1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo

HM Peshavariya, EC Chan, GS Liu, F Jiang, GJ Dusting

2014-01-01

Angiogenesis, the formation of new blood vessels, is a key physiological event in organ development and tissue responses to hypoxi..

In vivo tissue engineering chamber supports human induced pluripotent stem cell survival and rapid differentiation

SY Lim, DG Lee, P Sivakumaran, D Crombie, J Slavin, M Dottori, B Conley, M Denham, J Leung, R Tee, GJ Dusting, A Pebay, RJ Dilley

2012-05-25

Pluripotent stem cells are a potential source of autologous cells for cell and tissue regenerative therapies. They have the abilit..

Hypoxic preconditioning enhances survival of human adipose-derived stem cells and conditions endothelial cells in vitro

SL Stubbs, STF Hsiao, HM Peshavariya, SY Lim, GJ Dusting, RJ Dilley

2012-01-01

To grow more robust cardiac tissue for implantation in vivo, strategies to improve survival of implanted stem cells are required. ..

Differentiation of human adipose-derived stem cells into beating cardiomyocytes

YS Choi, GJ Dusting, S Stubbs, S Arunothayaraj, XL Han, P Collas, WA Morrison, RJ Dilley

2010-04-01

Human adipose-derived stem cells (ASCs) may differentiate into cardiomyocytes and this provides a source of donor cells for tissue..

Engineering cardiac tissue in vivo from human adipose-derived stem cells

YS Choi, K Matsuda, GJ Dusting, WA Morrison, RJ Dilley

2010-03-01

Cardiac tissue engineering offers promise as a surgical approach to cardiac repair, but requires an adequate source of cardiomyocy..

Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE -/- mice

CP Judkins, H Diep, BRS Broughton, AE Mast, EU Hooker, AA Miller, S Selemidis, GJ Dusting, CG Sobey, GR Drummond

2010-01-01

The Nox family NADPH oxidases are reactive oxygen species (ROS)-generating enzymes that are strongly implicated in atherogenesis. ..

3′,4′-Dihydroxyflavonol improves post-ischaemic coronary endothelial function following 7 days reperfusion in sheep

S Wang, CJ Thomas, GJ Dusting, OL Woodman, CN May

2009-12-10

3′,4′-dihydroxyflavonol (DiOHF) is a potent antioxidant that reduces infarct size following myocardial ischaemia-reperfusion. Sinc..

Translation-Linked mRNA destabilization accompanying serum-induced Nox4 expression in human endothelial cells

H Peshavariya, F Jiang, CJ Taylor, S Selemidis, CWT Chang, GJ Dusting

2009-10-01

NADPH oxidase is involved in cell signaling, regulating proliferation of vascular cells, especially in endothelium. The Nox4 catal..

NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival

H Peshavariya, GJ Dusting, F Jiang, LR Halmos, CG Sobey, GR Drummond, S Selemidis

2009-08-01

Proliferation and apoptosis of endothelial cells are crucial angiogenic processes that contribute to carcinogenesis and tumor prog..

Early increase of Nox4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious rats

SK McCann, GJ Dusting, CL Roulston

2008-08-15

Oxidative stress contributes to the progression of brain injury following ischemic stroke and reperfusion. NADPH oxidase is a well..

Using behaviour to predict stroke severity in conscious rats: Post-stroke treatment with 3′, 4′-dihydroxyflavonol improves recovery

CL Roulston, JK Callaway, B Jarrott, OL Woodman, GJ Dusting

2008-04-14

Prognostic models are used to predict outcome in stroke patients and to stratify treatment groups in clinical trials. No one has p..

Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells

S Selemidis, GJ Dusting, H Peshavariya, BK Kemp-Harper, GR Drummond

2007-07-15

Objective: Endothelial NADPH oxidase is a major source of superoxide in blood vessels and is implicated in the oxidative stress ac..